This new GWAS to possess locks colour within decide to try try typed in earlier times (Lin et al
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, Resource Lin, Mbarek, Willemsen, Dolan, Fedko and you can Abdellaoui 2015) therefore the results from this new GWAS to own eyes color was explained throughout the Second material. I duplicated the understood hereditary versions for attention color such as the HERC2 region getting brown attention colour (greatest SNP: rs74940492, Or = 0.09, p = 5.4E-8) as well as blue/grey vision color (ideal SNP: rs2240202, Or = , p = 1.0E-47); TYR and you can SLC24A4 to possess blue/grey (top SNPs: rs4904871, Otherwise = 0.71, p = 2.8E-13; rs67279079, Otherwise = 0.70, p = 3.1E-11) and eco-friendly/hazel eyes color (best SNPs: rs4904871, Or = 1.52, p = step 3.8E-20; rs67279079, Otherwise = step 1.44, p = step 3.6E-10). Of these recognized pigment hereditary variations, we recognized one to HERC2 have pleiotropic consequences toward blond, brownish, ebony tresses colour and you can blue/gray, brownish eye colour, and you may SLC24A4 have pleiotropic consequences into the blonde, brown, ebony hair colour and you can blue/gray and you may green/hazel eye colour.
The phenotypic association of eye and hair colors confirms the two traits to be strongly related in our sample (? 2 -test with 4 degrees of freedom gave a p value < 2.2?10 ?16 ): people with blond and red hair are likely to have blue/gray eyes while people with dark hair are more likely to have brown eyes. The counts and frequencies of the hair and eye color phenotypes for the 3,619 individuals (1,401 males; age: ± and 2,218 females; age: ±) are presented in Table 2(a), whereas Table 2(b) summarizes the information on the hair-eye color association from the much larger sample collected by Bolk ( Reference Bolk 1908), confirming the strong association in the Dutch population.
The brand new genetic correlations involving the locks and you may vision color are demonstrated for the Desk step 3. Right here, an identical loved ones was revealed as in the newest phenotypic description of the information and knowledge, where in fact the family genes linked to blond tresses reveal an effective positive correlation with bluish/gray colored vision and you may a terrible correlation that have brownish and you may eco-friendly coloured attention. Considering the lowest prevalence away from red-colored locks color inside our people, we really do not place one extreme hereditary overlap having any eye colour. …